يتناول هذا البروتوكول الكريوفيبرينوجينيميا المؤكدة في السياق المحدد حيث تم استبعاد الكريوغلوبولينيميا، ولم يُحدَّد أي سبب ثانوي كامن للكريوفيبرينوجينيميا، ولا يوجد دليل على مرض انسداد وعائي آخر.
DOI: 10.1093/rheumatology/kew379
Absence of cryoglobulinaemia. No secondary cause of cryofibrinogenaemia. No evidence of other vaso-occlusive disease.
In patients with secondary CF, effective management of the underlying disease is usually sufficient to achieve improvement, while approaches to treatment for essential CF in reported patients were variable and ranged from avoidance of cold exposure to aggressive immunosuppression and plasmapheresis.
Recently, healing of ulcers with colchicine and high-dose pentoxyfiline has been reported in one patient with CF who remained ulcer free for 2 years taking this combination.
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