علاج كريوفيبرينوجينيميا الأولية في غياب كريوغلوبولينيميا ودون سبب ثانوي

References

DOI: 10.1093/rheumatology/kew379

• Absence of cryoglobulinaemia
• No secondary cause of cryofibrinogenaemia
• No evidence of other vaso-occlusive disease
• Fibrinolysis may be considered in the acute phase in patients with severe ischaemic manifestations of CF, though the need for i.v. administration limits its use for prolonged treatment.
• Daily i.v. administration of alteplase at a low dose (10 mg) led to dramatic clinical improvement and the disappearance of CF.
• Some authors suggest that routine use of intravenous streptokinase or other fibrinolytics is justified in patients with CF, though in fact experience with this kind of treatment is quite limited.