العلاج الخط الأول لليمفوما البائية من المنطقة الهامشية خارج العقد اللمفاوية في الملتحمة المثبتة بالخزعة مع مرض أحادي الجانب وبدون إشراك جهازي

References

• The gold standard of conjunctival lymphoma diagnosis is an incisional biopsy for histopathological and cytological examination.
• A "wait and watch" strategy has been proposed for elderly or frail patients with little symptoms, particularly in the setting of unilateral disease.
• Subconjunctival instillation of 1–1.5 million international units (IU) of Interferon in 0.25 mL is advocated—with treatment frequencies up to 3 times weekly for 4–6 weeks, with further cycles advocated in the presence of incomplete response.
• An alternative dosing was proposed by Ferrari et al. who administered 1 to 2 mL of undiluted rituximab (10–20 mg/mL) plus 1 mL of 2% xylocaine.
• A dose range of 20–30 Gy was long advocated for management of these lesions, however recent literature suggests much lower doses can be used.
• In some cases, excisional biopsy or surgical resection may serve as therapy for well circumscribed conjunctival EMZL, however, in most cases attempts for complete resection should not be made because this does not influence survival and can lead to recurrence.