عندما يفشل الميثوتريكسات أحادي العامل في سرطان الأرومة الغاذية الحملية منخفض الخطورة بعد الحمل العنقودي الكامل

References

DOI: 10.1111/1471-0528.16266

• Women are assessed before chemotherapy using the FIGO 2000 scoring system (Table 1).
• Women with scores of 6 or less are at low risk and are treated with single-agent intramuscular methotrexate, alternating daily with folinic acid for 1 week followed by 6 rest days.
• Currently, 70% of women with a low-risk mole that scores 5 or 6 can expect to end up needing multi-agent chemotherapy to eliminate their disease.
• Women with scores of 7 or greater are at high risk and are treated with intravenous multi-agent chemotherapy, which includes combinations of methotrexate, dactinomycin, etoposide, cyclophosphamide and vincristine.
• Treatment is continued, in all cases, until the hCG level has returned to normal and then for a further 6 consecutive weeks.