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References

DOI: 10.1111/all.15090

• In CIndU, avoidance of specific and definite triggers for the development of signs and symptoms, for example, cold in cold urticaria, can reduce disease activity.
• We recommend a 2nd generation H1-antihistamine as first-line treatment for all types of urticaria.
• We recommend the use of a standard-dosed modern 2nd generation H1-antihistamines as the first-line symptomatic treatment for urticaria.
• Most but not all 2nd generation H1-antihistamines have been tested specifically in urticaria, and evidence supports the use of bilastine, cetirizine, desloratadine, ebastine, fexofenadine, levocetirizine, loratadine, and rupatadine.
• We suggest 2nd generation H1-antihistamines to be taken regularly for the treatment of patients with chronic urticaria.
• The goal of treatment is to treat the disease until it is gone and as efficiently and safely as possible aiming at a continuous UAS7 = 0, complete control and a normalization of quality of life.
• We recommend aiming at complete symptom control in urticaria, considering as much as possible the safety and the quality of life of each individual patient.