علاج متلازمة كوغان مع إصابة قوقعية دهليزية متوسطة إلى شديدة

References

• Unlike ocular involvement, cochleo-vestibular involvement has a poor prognosis and justifies the rapid introduction of immunosuppressive treatment or biologic therapy.
• Oral steroid therapy remains the most commonly used first-line treatment at a dosage of 1 mg/kg/day (not exceeding 60 mg/day unless in exceptional circumstances), sometimes preceded by intravenous methylprednisolone boluses (15 mg/kg/day for 3 days not exceeding 1 g per bolus).
• In moderate to severe forms or in case of failure or inadequate response, immunosuppressants are recommended (methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide) according to their use in vasculitis.
• Intratympanic steroid injections may be offered as adjunctive therapy to systemic treatment.

DOI: 10.1016/j.revmed.2024.09.007