علاج عدوى المطثية العسيرة الأولية غير الشديدة: عدد كريات الدم البيضاء أقل من 15,000 خلية/مم³ مع كرياتينين لا يتجاوز 1.5 ملغ/ديسيلتر

References

1. We recommend that oral vancomycin 125 mg 4 times daily for 10 days be used to treat an initial episode of nonsevere CDI (strong recommendation, low quality of evidence).
2. We recommend the following criteria, which are predictive of unfavorable outcomes, be used to classify severe C. difficile infection at the time of diagnosis: white blood cell (WBC) ≥15,000 cells/mm³ or serum creatinine >1.5 mg/dL.
3. We suggest tapering/pulsed-dose vancomycin for patients experiencing a first recurrence after an initial course of fidaxomicin, vancomycin, or metronidazole (strong recommendation, very low quality of evidence).
4. We recommend fidaxomicin for patients experiencing a first recurrence after an initial course of vancomycin or metronidazole (conditional recommendation, moderate quality of evidence).
5. Outcomes of interest in this patient population are sustained symptomatic cure defined as initial resolution of the diarrhea and no evidence of recurrence of diarrhea due to CDI.

DOI: 10.14309/ajg.0000000000001278