علاج متلازمة ألم المثانة عندما لم يتمكن أميتريبتيلين وبنتوسان بولي سلفات من السيطرة على الألم وتكرار التبول

References

• Primary bladder pain syndrome is the occurrence of persistent or recurrent pain perceived in the urinary bladder region, accompanied by at least one other symptom, such as pain worsening with bladder filling and daytime and/or night-time urinary frequency.
• There is no proven infection or other obvious local pathology.
• Offer intravesical lidocaine plus sodium bicarbonate prior to more invasive methods.
• Offer intravesical hyaluronic acid or chondroitin sulphate before more invasive measures.
• Offer intravesical heparin before more invasive measures alone or in combination treatment.
• Intravesical instillation of alkalised lidocaine or placebo for five consecutive days resulted in significantly sustained symptom relief for up to one month.
• Primary bladder pain syndrome patients were treated with heparin for three months, and over half had control of symptoms, with continued improvement after one year of therapy.