علاج ساركوما الغضروف في المظهر غير المتمايز (عالي الدرجة)

References

DOI: 10.1093/annonc/mdq223

• In rare circumstances conventional chondrosarcomas can 'dedifferentiate' into a very high-grade tumour with a dismal prognosis, so-called dedifferentiated chondrosarcoma.
• There remains uncertainty about chemotherapy sensitivity of dedifferentiated chondrosarcoma but it is often treated like osteosarcoma, with poorer outcome.
• There is a very high risk of local recurrence following excision of dedifferentiated chondrosarcoma, particularly in the presence of a pathological fracture.
• If wide margins cannot be reliably achieved with limb salvage then amputation should be considered.