صرع الغياب في الطفولة مع النوبة التوترية الرمعية المعممة: العلاج الخط الأول

References

VPA is the drug of choice as initial monotherapy in CAE when a generalized tonic–clonic seizure has occurred, because ETX is not effective against seizure types beyond absence seizures.

The target serum level is the level at which absence seizures stop occurring, both by parent report and by EEG—that is, there is no need to increase the dose to reach an arbitrarily set serum level.

However, for most patients, the therapeutic range is 50–100 µg/dL, and in the absence of side effects, serum levels can be pushed even higher to 120 µg/dL, or perhaps even 150 µg/dL.