ما هو علاج جدري الماء؟ العلاج بمضادات الفيروسات الفموية وإدارة الأعراض

References

DOI: 10.1016/j.jinf.2008.03.004

• While it is rare for patients to present within such a short time frame, a pragmatic approach is to consider antiviral agents in patients who present within 24–48 h of new vesicles, implying that the disease is still evolving.
• However, the bioavailability of oral aciclovir is poor, requiring dosing at 800 mg 5 times daily.
• The pro-drug valaciclovir, at a dose of 1 g 3 times daily, greatly enhances bioavailability, resulting in 3- to 4-fold higher plasma aciclovir levels that can be achieved with oral aciclovir.
• Famciclovir, the pro-drug of penciclovir, dosed at 500 mg 3 times daily, also has enhanced bioavailability when compared with aciclovir.
• A minimum of 1 week of antiviral therapy is recommended.
• Supportive therapy, such as anti-pruritic drugs can be helpful for all age groups.
• Mouthwashes and soothing topical lotions, plus anaesthetic gels for the genital area if there is mucosal involvement, are also useful for symptomatic treatment.
• Persisting fever with new vesicles >6 days after onset.