علاج ورم البطانة العصبية الدماغية المشخص حديثًا في الأطفال الذين تجاوزوا 18 شهرًا عندما لا يحقق الاستئصال الجراحي الإزالة الكاملة

DOI: 10.1093/neuonc/nox166

1. Key recommendations for the treatment of newly diagnosed intracranial WHO grades II and III ependymomas in children.
2. Postoperative conformal radiotherapy with doses up to 59.4 Gy is recommended in children older than 18 months.
3. Postoperative chemotherapy, using various combinations of etoposide, vincristine, cyclophosphamide, platinum derivatives, and high-dose methotrexate, showed a 40% to 50% response rate.
4. As there is reluctance to deliver radiation to very young children, postoperative chemotherapy has been frequently proposed, while in older children chemotherapy is delivered as an adjunct to radiotherapy.