علاج انقطاع النفس النومي المركزي الناجم عن التنفس الدوري على الارتفاعات العالية

References

DOI: 10.1183/20734735.0235-2023

• High altitude can promote respiratory instability during sleep (also known as high altitude periodic breathing (HAPB)).
• HAPB may be observed in altitudes >1600 m in healthy subjects, and the rates increase with increasing altitude.
• Meta-analysis data indicates the beneficial effects of acetazolamide in nocturnal hypoxaemia, periodic breathing time and AHI, potentially more apparent in healthy subjects and even at relatively small oral doses of 250 mg per day.
• Adding acetazolamide (750 mg·day−1) to auto-titrating CPAP improved nocturnal oxygen saturation and better controlled sleep disordered breathing than auto-titrating CPAP alone.