علاج الفقاع الشرياني مع انتكاسات متعددة أثناء تخفيض الكورتيكوستيرويد

References

Several therapeutic options can be discussed in patients who have multiple relapses during tapering of topical or systemic CS doses.

The addition of a conventional immunosuppressive drug may be recommended in the absence of contraindications, in particular methotrexate (5 to 12.5 mg weekly), mycophenolate mofetil (1 to 3 g daily) or azathioprine (1 to 3 mg/kg daily according to TPMT activity) (4.73 ± 0.83), although the level of evidence is lower for the latter drug.

In patients with poor general condition and/or in those with contraindications to immunosuppressive drugs, doxycycline (200 mg daily), dapsone (1 mg to 1.5 mg/kg daily) or omalizumab may also be considered (4.53 ± 0.90).