علاج متلازمة التهاب القصيبات المسد في متلقي زرع الرئة الذين يتلقون العلاج المناعي الصيانة القائم على السيكلوسبورين

References

DOI: 10.1183/09031936.00107514

• For lung transplant recipients who develop BOS while receiving chronic immunosuppression with a regimen that includes cyclosporine, we suggest switching the cyclosporine to tacrolimus (conditional recommendation, very low quality evidence).
• The conversion of cyclosporine to tacrolimus is generally performed by stopping cyclosporine and initiating tacrolimus while transiently increasing maintenance corticosteroid dosing until tacrolimus blood levels are ascertained to have reached the desired target range.
• The target for therapeutic trough blood levels of tacrolimus is generally considered to range from 5 to 15 ng/mL for patients who are ≥18 years of age once a steady state has been attained.