توسع القصبات: ماذا تفعل عندما تفشل تصفية مجرى الهواء في السيطرة على الأعراض

References

DOI: 10.1183/13993003.01126-2025

• We suggest to offer mucoactive treatments to patients with bronchiectasis where airway clearance has failed to control symptoms.
• Oral mucoactive agents, such as carbocisteine or N-acetylcysteine, reduce mucus viscosity, although evidence is limited.
• Nebulised hypertonic saline and inhaled mannitol hydrate mucus and stimulate cough to facilitate clearance.
• We suggest not to offer recombinant DNase to patients with bronchiectasis.
• If no clinical benefit is evident after a reasonable trial period (e.g. 3 months), treatment should be discontinued.