داء بوين في الساق السفلية عندما لا يحقق العلاج الخط الأول تطهير الآفة

References

DOI: 10.1093/bjd/ljac042

• Consider topical 5-fluorouracil (5%) monotherapy in people with SCC in situ, for larger lesions on poorly healing sites (e.g. the lower legs of older patients) as a practical alternative to surgical treatments. Initiate a standard regimen of once- or twice-daily application for up to 4 weeks (see R9).
• For immunocompetent people with SCC in situ lesions located on the lower legs, use* treatments other than radiotherapy (apart from brachytherapy), due to prolonged healing time.
• Consider topical imiquimod in people with SCC in situ lesions located on the lower legs who are inappropriate for, have contraindication to or have inadequate response to topical 5-fluorouracil (5%), PDT, laser, curettage with cautery, or surgery (see R31).
• Consider cryotherapy on an individual basis, in people with SCC in situ with larger lesions, and those on the lower leg (see R15). Consider patient factors (age, location, skin health) and discuss the risk of prolonged healing and potential ulceration. The time of freezing may need to be shortened to avoid complications, but this is associated with a reduction in effectiveness.