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References

DOI: 10.1016/j.jaad.2017.10.006

Patients had at least 1 tumor 10 mm or larger in diameter that was considered inoperable or inappropriate for surgery in the opinion of a specialist in MMS, head and neck surgery, or plastic surgery.

If surgery and radiation therapy are contraindicated or inappropriate for the treatment of locally advanced BCC, or if residual tumor persists following surgery and/or radiation therapy and further surgery and radiation therapy are contraindicated or inappropriate, systemic therapy with a smoothened inhibitor should be considered.

Comparable findings were more recently reported with use of another SMO inhibitor, sonidegib, in patients with locally advanced BCC.

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