علاج تلف الكبد ذي النمط المناعي الذاتي التالي للتعرض للأدوية أو الأعشاب أو المكملات الغذائية أو اللقاحات

References

DOI: 10.1016/j.jhep.2025.03.017

• DILI associated with an autoimmune phenotype, i.e. the presence of autoantibodies, high IgG levels and/or histological evidence of autoimmunity in the liver, should be considered as possible DI-ALH (LoE 2, strong recommendation, strong consensus).
• In suspected cases of DI-ALH, the potential causative agent should be immediately withdrawn (LoE 2, strong recommendation, strong consensus).
• In patients with severe hepatitis or impaired liver function or no improvement of liver tests within 30 days of discontinuation of the implicated agent, a short course of predniso(lo)ne is recommended (LoE 4, strong recommendation, strong consensus).
• Predniso(lo)ne at an initial dose of 0.5 mg/kg/day followed by rapid tapering until complete withdrawal within 1-2 months is recommended (LoE 5, strong recommendation, strong consensus).