علاج الاستسقاء في تشمع الكبد عندما يتجاوز عدد عدلات سائل الاستسقاء 250 خلية/مم³

References

DOI: 10.1136/gut.2006.099580

• The diagnosis of SBP is confirmed when ascitic neutrophil count is >250 cells/mm³ (0.25×10&sup9;/l) in the absence of an intra-abdominal and surgically treatable source of sepsis.
• In patients with an ascitic fluid neutrophil count of >250 cells/mm³, empiric antibiotic therapy should be started.
• Third generation cephalosporins such as cefotaxime have been most extensively studied in the treatment of SBP and have been shown to be effective.
• Other cephalosporins, such as ceftriaxone and ceftazidime as well as co-amoxiclav (amoxicillin plus clavulanic acid), have been shown to be as effective as cefotaxime in resolving SBP.
• A reduction in ascitic fluid neutrophil count of less than 25% of the pretreatment value after two days of antibiotic treatment suggests failure to respond to therapy.
• Resolution of infection in SBP is associated with an improvement in symptoms and signs.