التهاب الفم القلاعي المتكرر عندما لا تتحكم العوامل الموضعية في القرحات

References

1. Drug therapy is considered for patients who experience multiple episodes of RAS each month and/or present with symptoms of severe pain and difficulty in eating.
2. It is indicated for severe and constantly recurring ulcerations; topical management is not effective in these cases.
3. Pakfetrat et al. conducted a double-blind randomized clinical trial to compare colchicine versus prednisolone (immunomodulant agents) in RAS and reported that low dose prednisolone and colchicine were both effective in treating RAS.
4. de Abreu et al. reported that clofazimine should be considered for the treatment of RAS.
5. In severe cases of RAS, immunosuppressive and anti-inflammatory drugs have shown varying degrees of success.
6. Drugs commonly used include corticosteroids, dapsone, colchicine, thalidomide.
7. The aim of the treatment of RAS is to decrease symptoms; reduce ulcer number and size; increase disease-free periods.