التهاب الفم القلاعي المتكرر مع نوبات شهرية متعددة وصعوبة في الأكل — عندما لا يكفي العلاج الموضعي

References

• Drug therapy is considered for patients who experience multiple episodes of RAS each month and/or present with symptoms of severe pain and difficulty in eating.
• It is indicated for severe and constantly recurring ulcerations; the topical management is not effective in these cases.
• Pakfetrat et al.,38 have conducted a double-blind randomized clinical trial to compare colchicine versus prednisolone (immunomodulant agents) in RAS and reported that low dose prednisolone and colchicine were both effective in treating RAS.
• de Abreu et al.,39 reported that clofazimine should be considered for the treatment of RAS.
• In severe cases of RAS, immunosuppressive, and anti-inflammatory drugs have shown varying degrees of success.
• The aim of the treatment of RAS is to decrease symptoms; reduce ulcer number and size; increase disease-free periods.