علاج الجمرة الخبيثة عند اختلاط الإنتان أو الوذمة الواسعة بالمرض الجلدي

References

• Systemic anthrax is defined as any of the following: 1) Cutaneous anthrax with systemic illness, sepsis and/or extensive oedema (hereafter referred to as severe cutaneous anthrax).
• In the presence of any of these scenarios, empiric combination therapy with two antibiotics is recommended.
• The first agent should be selected from ciprofloxacin, ampicillin, or penicillin G, based on local penicillin susceptibility patterns (Table 4).
• The second agent should be chosen according to the clinical presentation: intravenous clindamycin for inhalation or injection-related anthrax, oral clindamycin for severe cutaneous anthrax, or intravenous gentamicin for gastrointestinal anthrax.
• Overall, treatment duration should be extended for at least 14 days or until the patient is clinically stable, whichever is longer.
• For severe cutaneous anthrax, when symptoms cease and temperature normalizes, monotherapy can be considered.