ما هو علاج فقر الدم في الأمراض المزمنة؟ العلاج بالحديد كخط أول

References

DOI: 10.1016/j.kint.2025.06.006

• Oral iron preparations are available as iron salts or iron carbohydrates and are the therapy of choice in AI subjects with true iron deficiency and mild inflammation, in whom they show an efficacy that is comparable to IV preparations.
• In general, oral iron preparations should be taken once in the morning at a minimum dose of 50 mg of ferrous iron (the total compound dose depends on the specific iron salt or glycan used).
• Ascorbic acid and overnight fasting can increase iron bioavailability, whereas proton pump inhibitors or several foods, including milk products and tea, decrease iron absorption.
• I.V. iron if intolerance to oral iron, gastrointestinal uptake problems (hepcidin), or short timeline before surgery.
• A successful therapeutic trial of iron would confirm absolute iron deficiency.
• Of note, hepcidin levels may predict the response to therapy with oral iron, and if treatment with oral iron has not been efficient after 2 weeks, a switch to IV iron is indicated.