علاج مرض ألزهايمر مع اللامبالاة

References

Apathy is present at the onset of Alzheimer's disease in about half of patients, irritability in one-third, and depression, agitation, and sleep disturbances in one-quarter.

There is some indication that both stimulants, such as methylphenidate, and cholinesterase inhibitors might improve apathy in people with Alzheimer's disease, whereas agomelatine, a melatonin receptor agonist and serotonin receptor blocker, might be useful for treating apathy in people with frontotemporal dementia.

However, the evidence for these treatments is mainly from case series, and pharmacological therapy should probably be reserved for severe cases of apathy.