الثلاسيميا ألفا الكبرى (استسقاء الجنين بالهيموغلوبين بارت): الإدارة عندما لا يحقق الاستخلاب الحديدي تركيز الحديد المستهدف في الكبد

Once an infant with α-thalassaemia major (haemoglobin Bart’s hydrops foetalis) survives the neonatal period, they will become lifelong transfusion-dependent, unless they are cured by haematopoietic stem cell transplantation.

Allogeneic haematopoietic stem cell transplantation is the only curative option currently available for long term survivors of haemoglobin Bart’s hydrops foetalis.

Transplant for thalassaemia should be offered as early as possible as outcomes are superior prior to the onset of organ dysfunction secondary to iron overload.

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