علاج ألفا ثلاسيميا الصغرى بعد فشل نقل الدم في الحفاظ على مستويات الهيموغلوبين المستهدفة في الثلاسيميا الكبرى (استسقاء الجنين بهيموغلوبين بارت)

References

1. Once an infant with α-thalassaemia major (haemoglobin Bart's hydrops foetalis) survives the neonatal period, they will become lifelong transfusion-dependent, unless they are cured by haematopoietic stem cell transplantation.
2. Iron chelation is started at approximately one year of age, with careful monitoring for toxicities.
3. The goal of chelation is to maintain liver iron concentration to < 7 mg/g of dry weight, and ideally between 2–5 mg/g dry weight, measured through magnetic resonance imaging (MRI).