علاج داء النشواني AL مع قصور القلب الاحتقاني (إصابة القلب)

References

DOI: 10.1200/OP.22.00396

In patients with congestive heart failure from AL amyloidosis, standard-of-care therapy agents such as renin-angiotensin system blockers and beta blockers are poorly tolerated as they exacerbate hypotension and suppress the compensatory sinus tachycardia, respectively, leading to hemodynamic instability and therefore to increased morbidity and mortality.

The use of loop diuretics (eg, furosemide) with aldosterone antagonists (eg, spironolactone) is usually the mainstay of therapy, with sometimes the addition of midodrine to improve hypotension.