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References

• Pyrimethamine, considered the most effective drug against toxoplasmosis, is a standard component of therapy.
• Pyrimethamine is a folic acid antagonist and can cause dose-related suppression of the bone marrow, which is mitigated by concurrent administration of folinic acid (leucovorin).
• Leucovorin protects the bone marrow from the toxic effects of pyrimethamine.
• A second drug, such as sulfadiazine or clindamycin (if the patient has a hypersensitivity reaction to sulfa drugs), should also be included.