ما هو علاج داء النسيجات الرئوي الحاد المعتدل في المريض ذي المناعة السليمة؟

References

DOI: 10.1093/cid/ciaf256

• In immunocompetent adults and children presenting with moderate acute pulmonary histoplasmosis, the panel suggests either antifungal treatment or no antifungal treatment, considering the severity and duration of signs/symptoms, as well as potential harms of antifungal treatment (conditional recommendation, very low certainty of evidence).
• Moderate acute pulmonary histoplasmosis — Symptoms (eg, cough, fever, dyspnea, chest discomfort) significant enough to interfere with normal activities; may require low-flow oxygen supplementation or hospitalization.
• When treatment is indicated, itraconazole is preferred.
• A goal trough concentration of itraconazole component >1 mg/L and <3–4 mg/L (as measured by chromatographic assay) is associated with efficacy and a lower risk of toxicity.