ما هو علاج الخط الأول لسرطان الدم الليمفاوي الحاد؟

References

• Chemotherapy induction regimens for ALL generally use a combination of drugs that include vincristine; an anthracycline (daunorubicin or doxorubicin); and a corticosteroid (prednisone or dexamethasone).
• Based on their risk group, some patients may also receive cyclophosphamide or pegaspargase.
• In addition to chemotherapy, patients may also receive a monoclonal antibody such as inotuzumab ozogamicin (Besponsa®), ofatumumab (Kesimpta®) or rituximab (Rituxan®).
• Intrathecal chemotherapy, in which anticancer drugs are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord. These drugs may include methotrexate, cytarabine, and corticosteroids (typically, hydrocortisone).
• Induction therapy often lasts about 4 weeks.
• No more than 5 percent of cells in the bone marrow are blast (immature) cells; no blasts are found in the blood; blood cell counts are back to normal/near normal; all signs and symptoms of ALL are gone.