علاج AGEP مع الإصابة الجهازية أو الحمامى

References

DOI: 10.1111/jdv.20232

• The suspected causal drug(s) must be stopped immediately and the pharmacovigilance department should be advised as soon as possible.
• All patients should be placed on bed rest until significant improvement and receive supportive care including mild soap substitutes baths or showers, moisturizing cream and oral or intravenous hydration according to the clinical status and biological changes.
• For the most severe patients (extensive skin lesions and pseudo-Nikolsky sign), supportive care could be based on the existing recommendations for epidermal necrolysis.
• In the most severe cases, that is, with systemic involvement (e.g. liver or kidney abnormalities and haemodynamic instability) or very acute skin lesions (erythroderma and disseminated pustules), a short systemic corticosteroid therapy with prednisone 0.5 mg/kg/day for a duration of 5–7 days may be considered.

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