علاج ضخامة النهايات مع انقطاع النفس الانسدادي النومي أو قصور القلب عالي النتاج عندما لم تصل المعالجة الطبية قبل الجراحة إلى أهدافها

For patients with severe pharyngeal thickness and sleep apnea, or high-output heart failure, we suggest medical therapy with SRLs preoperatively to reduce surgical risk from severe comorbidities.

We recommend transsphenoidal surgery as the primary therapy in most patients.

A serum GH < 0.14 µg/L suggests "surgical remission," and a level < 1 µg/L indicates "control" and normalization of the mortality risk.

IGF-1 levels measured at 12 weeks after surgery are a valid reflection of surgical remission.

DOI: 10.1210/jc.2014-2700 View source ↗