علاج ضخامة النهايات المُقدِّمة كعملقة تنشأ في مرحلة الطفولة أو البلوغ

Gigantism is caused by very rarely encountered sporadic or familial GH-secreting adenomas arising during childhood or puberty.

GH hypersecretion occurring before epiphyseal closure results in excessive linear growth and phenotypic features of gigantism due to both elevated GH and IGF-1 levels.

Surgery is the first line of therapy, although adjuvant therapy is often required.

In patients with the rare presentation of gigantism, we recommend the standard approaches to normalizing GH and IGF-1 hypersecretion as described elsewhere in this guideline.

DOI: 10.1210/jc.2014-2700