Antiphospholipid syndrome
ICD-10 D68.6 · ICD-11 4A45

Treatment of Antiphospholipid Syndrome in Non-Pregnant Women with a History of Obstetric APS

This protocol addresses the prophylactic management of antiphospholipid syndrome (APS) in women who are not currently pregnant, have a documented history of obstetric APS, and have no prior thrombotic events.

Clinical Scenario

The patient is female, not pregnant, and presents with a history of obstetric antiphospholipid syndrome — without any history of arterial or venous thrombotic events. In this setting, prophylactic management requires careful individual risk–benefit evaluation before initiating or continuing therapy.

Prophylactic Approach

Current evidence supports a prophylactic antiplatelet strategy for eligible women in this scenario. The regimen involves a single oral antiplatelet agent; the complete specification — including dose, schedule, and individualization criteria — is detailed in the full structured protocol.

References

DOI: 10.1136/annrheumdis-2019-215213

In non-pregnant women with a history of obstetric APS only (with or without SLE), prophylactic treatment with LDA after adequate risk/benefit evaluation is recommended.

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