This protocol addresses antiphospholipid syndrome (APS) in female patients who had a prior delivery before the 34th week of gestation caused by eclampsia, severe pre-eclampsia, or recognised placental insufficiency, and who have no history of thrombotic events.
Clinical scenario: Female patient with confirmed antiphospholipid syndrome, prior delivery before 34 weeks of gestation due to eclampsia, severe pre-eclampsia, or placental insufficiency, and no prior thrombotic events.
In this setting, management during pregnancy involves antiplatelet therapy — with or without the addition of prophylactic anticoagulation — selected according to the individual's risk profile. The full structured regimen is available via the link below.
DOI: 10.1136/annrheumdis-2019-215213
With a history of delivery <34 weeks of gestation due to eclampsia or severe pre-eclampsia or due to recognised features of placental insufficiency, treatment with LDA or LDA and heparin at prophylactic dosage is recommended considering the individual's risk profile.
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