Treatment of Antiphospholipid Syndrome in Catastrophic Antiphospholipid Syndrome
Clinical Scenario
This protocol covers the first-line management of antiphospholipid syndrome presenting as catastrophic antiphospholipid syndrome (CAPS) — a severe, rapidly evolving manifestation requiring immediate, coordinated intervention.
Treatment Approach
First-line management of CAPS relies on a multi-agent combination strategy rather than single-agent therapy. Addressing any identifiable triggering factor is also part of the approach.
The complete regimen — including specific agents, sequencing, and clinical guidance — is available in the full protocol…
References
DOI: 10.1136/annrheumdis-2019-215213
- For first-line treatment of patients with CAPS, combination therapy with glucocorticoids, heparin and plasma exchange or intravenous immunoglobulins is recommended over single agents or other combinations of therapies.
- Additionally, any triggering factor (eg, infections, gangrene or malignancy) should be treated accordingly.
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