This protocol applies to patients aged 3 years or older presenting with anti-NMDA-receptor encephalitis who meet 4 of 6 clinical criteria and at least 1 of 2 abnormal laboratory criteria for autoimmune encephalitis, with severe autonomic instability present.
The patient satisfies 4 of 6 clinical criteria and 1 of 2 abnormal laboratory criteria for autoimmune encephalitis. Severe autonomic instability is documented, marking this as a high-acuity presentation that requires prompt, structured intervention.
This presentation calls for immediate admission to an intensive care setting alongside a plasma-based blood-purification approach and specialist involvement. The complete protocol details the full sequence and all required steps — access it below.
DOI: 10.1212/CPJ.0000000000200218