Treatment of Angle-Closure Glaucoma with ≥180° Iridotrabecular Contact (ITC) on Gonioscopy and No IOP Elevation

This protocol covers a specific early structural risk state: gonioscopy showing ≥180 degrees of iridotrabecular contact, but with normal intraocular pressure, no peripheral anterior synechiae, and no glaucomatous optic neuropathy — a configuration known as a primary angle-closure suspect (PACS).

Clinical Scenario

Gonioscopy confirms ≥180° of iridotrabecular contact (ITC). Intraocular pressure is within normal limits. No peripheral anterior synechiae (PAS) are identified. There is no evidence of glaucomatous optic neuropathy. This constellation defines a primary angle-closure suspect (PACS) — an eye at structural risk despite the current absence of pressure elevation or optic nerve damage.

Approach & Goals

In this setting, a laser procedure targeting the peripheral iris is considered to reduce the risk of an acute angle-closure crisis or progression to more advanced angle-closure disease. The complete protocol specifies the clinical indication criteria, procedural details, and follow-up requirements.

The primary treatment goal is confirmation that the anterior chamber angle has opened, verified by repeat gonioscopy following intervention.

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References

DOI: 10.1016/j.ophtha.2025.12.030 View source ↗