First-Line Treatment for Locally Advanced or Metastatic Ampullary Carcinoma with Proficient Mismatch Repair (pMMR)
This protocol covers the first-line systemic treatment approach for patients with locally advanced or metastatic ampullary carcinoma who have proficient mismatch repair (pMMR) status, a pancreatobiliary (PB) or mixed (MT) histological subtype, and an ECOG performance status of 2 or below.
Clinical Scenario
- Locally advanced or metastatic ampullary carcinoma
- Proficient mismatch repair (pMMR)
- Pancreatobiliary (PB) or mixed (MT) subtype
- ECOG performance status ≤ 2
Treatment Approach
First-line chemotherapy is recommended, with the choice of regimen adapted to the patient's general condition and tumour subtype. The full structured protocol specifies the recommended options — access it below.
References
DOI: 10.1016/j.dld.2024.04.027
For pMMR AC, first line chemotherapy may be adapted according to general condition, and INT / PB / MT subtype:
modified FOLFIRINOX without bolus (expert opinion)
Gemcitabine based chemotherapy: gemcitabine +/- cisplatin (expert opinion)
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