Adjuvant Treatment of Resected Stage IIIB–IV Melanoma with No Evidence of Disease

This protocol addresses patients with amelanocytic melanoma who have undergone complete surgical resection and present as resected stage IIIB–IV disease with no evidence of disease (NED), or as resected stage III cutaneous melanoma.

Adjuvant systemic therapy initiated within a defined window after complete resection is central to management. The appropriate approach differs depending on disease stage and tumour molecular characteristics.

The complete regimen — including specific agents, eligibility criteria, sequencing, and timing — is available in the full structured protocol below.