In some patients with unresectable amelanocytic melanoma, standard systemic treatment is either not medically appropriate or not the patient's preference. When lesions remain accessible for direct injection — whether cutaneous, subcutaneous, or nodal — a distinct therapeutic approach applies.
Patients with injectable unresectable melanoma lesions (cutaneous, subcutaneous, or nodal) who are not eligible for, or not desiring, recommended systemic therapies. In this setting, a locally directed primary therapy may be offered.
An oncolytic viral therapy administered directly into accessible lesions may be offered as primary therapy in this population. Full regimen details, sequencing, and eligibility criteria are in the complete protocol →
DOI: 10.1200/JCO.23.01136