Treatment of Alzheimer's Disease with Depression

Depression is a recognised neuropsychiatric feature that can arise in the course of Alzheimer's disease. Addressing it requires a structured, patient-centred approach tailored to this specific clinical situation.

Clinical Scenario

This protocol targets patients with Alzheimer's disease who have depression. Depression tends to be common in the early stages of Alzheimer's disease, making its identification and active management a central part of the overall care plan.

Treatment Approach

The protocol for this scenario centres on non-pharmacological, personalised strategies — including individually tailored activity and an exercise component. The complete regimen, including the full structure and specific elements, is available via the link below.

Instant Access to Structured Evidence-Based Regimens

References

Depression is common early on, whereas psychosis is more frequent in the moderate stage, with insomnia and apathy increasing in severe stages.
Personalised activities and enjoyable exercise have shown benefits for depression and apathy with effect sizes between 0·2 and 0·5.

DOI: 10.1016/S0140-6736(25)01329-7

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