Treatment of Alpha Thalassemia Minor in Haemoglobin H Disease Presenting with Acute Haemolytic Crisis

In Haemoglobin H disease, acute haemolytic crisis is a recognised dominant clinical feature. It presents as acute worsening of anaemia, frequently accompanied by jaundice and/or dark-coloured urine, requiring prompt assessment and intervention.

The primary objective in this acute setting is to restore haemoglobin to 80–90 g/L.

Management centres on red cell transfusion together with adequate intravenous hydration. Additional targeted measures are applied according to clinical findings present at the time of the episode.

The complete structured protocol — including all interventions, selection criteria, and empirical therapy guidance — is available in the full regimen below.