Patients with AL amyloidosis who have relapsed after or failed to respond to prior therapy present a difficult clinical challenge. When the t(11;14) chromosomal translocation is present, this molecular finding defines a specific sub-population for whom a distinct treatment approach is supported by the literature.
Clinical scenario: Relapsed or refractory AL amyloidosis in a patient harbouring the t(11;14) translocation. The presence of this cytogenetic finding is the defining feature of this patient sub-group.