This protocol covers rhodesiense human African trypanosomiasis in patients who are either under 6 years of age or have a body weight below 20 kg, and who present with a CSF white blood cell count of 5/µL or below with no trypanosomes detected in the cerebrospinal fluid.
In this patient population, fexinidazole may be available as a compassionate rescue treatment. Because specific dosage and administration guidance is required, a medical specialist must be consulted. The complete regimen and all clinical guidance are provided in the structured protocol.
Suramin is the first-choice treatment in patients aged < 6 years or body weight < 20 kg presenting with ≤ 5 WBC/µL in CSF and no trypanosomes in CSF.
In a post-melarsoprol relapse, a compassionate rescue treatment with fexinidazole can be considered.
In such exceptional cases, a medical specialist should be consulted for dosage and administration.
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