Acute toxoplasmosis
ICD-10 B58.9 · ICD-11 1F57.Z

Treatment of Acute Toxoplasmosis in Pregnancy When Infection Is Acquired at or After 18 Weeks Gestation

Acute toxoplasmosis during pregnancy requires a tailored management strategy that depends on gestational age at the time of infection. When infection is acquired at or after 18 weeks, or when fetal involvement is documented or suspected, a more intensive treatment approach is indicated.

Clinical scenario Pregnant woman with Toxoplasma infection acquired at or after 18 weeks gestation, or with documented or suspected fetal infection — a situation in which a more targeted antiparasitic regimen is recommended over watchful waiting or the approach used earlier in pregnancy.

Treatment approach

A specific combination antiparasitic regimen that includes pyrimethamine is indicated in this setting. The complete protocol — specifying all agents, their roles, and sequencing — is available in the full structured regimen below.

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References

Pyrimethamine, sulfadiazine and leucovorin are recommended for infections acquired at or after 18 weeks gestation or infection in the fetus is documented or suspected.

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