Acute rheumatic fever requires prompt antibiotic treatment to eradicate the underlying streptococcal infection. The choice of agent and route of administration are guided by clinical context — including any history of penicillin hypersensitivity.
Management centres on antibiotic therapy directed at clearing the streptococcal infection. Options vary depending on allergy history and clinical presentation — the complete regimen, including preferred agents, alternatives, and the decision algorithm, is detailed in the full protocol.