This protocol addresses early acute respiratory failure arising in the context of immunosuppression. Immunocompromised patients represent a distinct and high-risk sub-population in whom the choice of initial respiratory support strategy has direct implications for outcomes.
In patients with immunocompromised states, early acute respiratory failure requires a carefully selected respiratory support approach. International guidelines specifically distinguish this population and recommend a targeted ventilatory strategy distinct from general ARF management.
The recommended first-line intervention for this scenario involves a noninvasive positive pressure strategy. The specific mode, clinical criteria for initiation, monitoring targets, and escalation thresholds are defined in the full protocol.
DOI: 10.1186/s40560-023-00658-3
The European Respiratory Society (ERS)/ATS guidelines recommend bilevel positive airway pressure (bilevel-PAP) for patients with acute exacerbation of COPD accompanied by acute hypercarbia, CPAP for cardiogenic pulmonary edema, and NPPV for post-operative setting and early ARF in immunosuppressed patients.
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