This protocol addresses patients with confirmed acute myocarditis in whom endomyocardial biopsy reveals a lymphocytic inflammatory infiltrate and a thorough viral workup is negative — a distinct subset with an immune-mediated rather than infectious aetiology.
Lymphocytic myocarditis, virus-negative: lymphocytic infiltration of the myocardium without an identifiable viral trigger. The absence of a viral cause directs management toward immunomodulatory strategies.
Management involves oral corticosteroids combined with an immunosuppressant agent. Agent selection and the complete regimen are detailed in the full protocol.
DOI: 10.1093/eurheartj/ehaf192